Polimorfismos de nucleotido simple asociados a servicios por concepción en cerdas infectadas con el virus del PRRS
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El síndrome respiratorio y reproductivo porcino (PRRS) es una enfermedad que genera pérdidas económicas en la porcicultura mundial y se caracteriza por afectar el desempeño reproductivo de las cerdas. El objetivo del estudio fue identificar polimorfismos de nucleótido simple (SNP) asociados al número de servicios por concepción en la primera gestación (NSC1) en cerdas reproductoras infectadas naturalmente por el virus del PRRS. La investigación incluyó 53 hembras de la línea Landrace/Yorkshire previamente detectadas como positivas al virus del PRRS a través de PCR. Una muestra de sangre de cada una de las hembras fue recolectada y fijada en tarjetas FTA-CardsTM. Las tarjetas fueron enviadas al laboratorio Geneseek para la genotipificación de 10,000 SNP. Un modelo de efectos mixtos identifico una asociación (P<0.001) entre el NSC1 con los SNPs rs81364943, rs81382736, rs80976363, rs80890869 y rs81460050. El efecto de sustitución alélica fue calculado usando un modelo de regresión que incluyó el término genotipo como covariable, el cual demostró un incremento en la variable NSC1 de 0.41 ± 0.15, 0.11 ± 0.07, 0.23 ± 0.08, 0.15 ± 0.11 y 0.20 ± 0.09 para los cinco SNP, respectivamente. Los resultados encontrados indican la existencia de bases genéticas asociada a la eficiencia reproductiva en hembras porcina infectadas por el PRRS.
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Aguilar-Trejo, C. M. (2017). Polimorfismos de nucleotido simple asociados a servicios por concepción en cerdas infectadas con el virus del PRRS. Revista Latinoamericana De Recursos Naturales, 13(2). Recuperado a partir de https://revista.itson.edu.mx/index.php/rlrn/article/view/262
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Aguilar-Trejo, C.M., Valerio-Valle, K.M., Luna-Ramirez, R.I., Luna-Nevarez, G., Reyna-Granados, J.R., Romo, J.A., Sanchez-Castro, M.A., Zeng, X., Enns, R.M., Speidel, S.E., Thomas, M.G., y Luna-Nevarez, P. 2017. Validation of candidate markers associated with reproductive performance in porcine respiratory and reproductive syndrome virus naturally infected replacement gilts in southern Sonora México. J. Anim.Sci. 95(4):29
Alonso, C., Murtaugh, M.P., Dee, S. A. & Davies, P.R. 2013. Epidemiological study of air filtration systems for preventing PRRSV infection in large sow herds. Prev. Vet. Med. 112(1–2):109–17 Balding, D.J. A.
Bergfelder-Drüing, S., Grosse-Brinkhaus, C., Lind, B., Erbe, M., Schellander, K., Simianer, H., & Tholen, E. 2015. A Genome-Wide Association Study in Large White and Landrace Pig Populations for Number Piglets Born Alive. PLoS ONE 10(3).
Boddicker, N., E.H. Waide, R.R.R. Rowland, J.K. Lunney, D.J. Garrick, J.M. Reecy, and J.C.M. Dekkers. 2012. Evidence for a major QTL associated with hot response to Porcine Reproductive and Respiratory virus syndrome challenge. J. Anim. Sci. 90:1733.
Chand R.J., Trible B.R, Rowland R.R.R. 2012. Pathogenesis of porcine reproductive and respiratory syndrome virus. Current Opinion in Virology: 2:256–263.
Charerntantanakul, W. Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects. 2012. World. J. Virol. 1(1):23–30.
Collins J.E., Mollitor T.W., Shin J.R., Pijoan C., Casamiglia M., Kapur V. 1999. Necesidad de los Médicos Veterinarios de diagnosticar enfermedades porcinas, por medio de la Reacción en Cadena de la Polimerasa (PCR). Memorias del curso “Actualidades en la Producción Porcina y en el diagnóstico de Enfermedades, México, D.F. 13-18
Flores-Mendoza, L. y Hernández, J. 2001. Vacunas contra el virus del síndrome reproductivo y respiratorio porcino (PRRSV): escribiendo una historia. Vet. México. 41:139-159.
Geldhof M.F., Breedam W.V., Jong E., Rodriguez A.L., Karniychuk U.U., Vanhee M, Doorsselaere Jv, Maes D,. Nauwynck H.J. 2013. Antibody response and maternal immunity upon boosting PRRSV-immune sows with experimental farm-specific and commercial PRRSV vaccines. Vet Microbiol;167:260–271.
Habier D., Fernando R. L., Kizilkaya K., Garrick D. J. 2011. “Extension of the Bayesian Alphabet for Genomic Selection”. BMC Bioinformatics 12:186.
Hanenberg, E. H. A. T., Knol, E. F. y Merks, J. W. M. 2001. Estimates of genetic parameters for reproduction traits at different parities in Dutch Landrace pigs. Livest. Prod. Sci. 69: 179-186.
Holtkamp D.J., Kliebenstein J.B., Neumann E.J., Zimmerman J.J., Rotto H.F., Yoder T.K., Wang C., Yeske P.E., Mowrer C.L., Haley C.A. 2013. Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. J Swine Health Prod; 21:72–84
Kikuchi M., Hatano N., Yokota S., Shimozawa N., Imanaka T., Taniguchi H. 2004. Proteomic analysis of rat liver peroxisome: Presence of peroxisome-specific isozyme of Lon protease. J Biol Chem. 2;279(1):421-8.
Kleiboeker, S. B., Schommer, S. K., Lee, S. M., Watkins, S., Chittick, W. & Polson, D. 2005. Simultaneous detection of North American and European porcine reproductive and respiratory syndrome virus using real-time quantitative reverse transcriptase–PCR. Journal Vet. Diagn. Invest. 17:165-170.
Koning D.J., Rattink B., Harlizius M.A., Groenen E.W., Brascamp 2001. Detection and characterization of Quantitative Trait Loci for growth and reproduction traits in pigs. Livestock Production Science. 72: 185-198
Lewis T. W., Wiseman J., Woolliams J.A. 2005. Genotype by mating type interaction for litter size in Landrace and Large White sows. Anim. Sci.; 81: 331-335
Lewis C.R., Ait-Ali T., Clapperton M., Archibald A.L., Bishop, S. 2007. Genetic perspectives on host responses to porcine reproductive and respiratory syndrome (PRRS). Viral Immunol ;20(3), 343-358.
Lewis C.R., Torremorell M., Galina P.L., Deeb N., Mellencamp M.A., Archibald A.L. Bishop S. A genomewide association analysis identifying SNPS for PRRS tolerance on a commercial pig farm. Proc. Assoc. Advmt. J Anim Breed Genet. 2009; (18)187–190.
Lunney J.K., Steibel J.P., Reecy J.M., Fritz E., Rothschild M.F. 2011. Probing genetic control of swine responses to PRRSV infection: current progress of the PRRS host genetics consortium. BioMed Central Ltd. pp. S30
Lunney J.K., Chen H. 2010. Genetic control of host resistance to porcine reproductive and respiratory syndrome virus (PRRSV) infection. Virus Research. 154:161–169.
Rothschild, M., Jacobson, C., Vaske, D., Tuggle, C., Wang, L., Short, T., Eckardt, G., Sasaki, S., Vincent, A., McLaren, D., Southwood, O., van der Steen, H., Mileham, A. & Plastow, G. 1996. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. . Proc Natl Acad Sci USA 93: 201–205.
Rowland R.R, 2012. Pathogenesis of porcine reproductive and respiratory syndrome virus. Current Opinion in Virology;2:256–263.
Serão, N.V.L., Matika, O., Kemp, R. A., Harding, J.C., Bishop, S. C., Plastow, G. S. & Dekkers, J.C. M. 2014. Genetic analysis of reproductive traits and antibody response in a PRRS outbreak herd. J. Anim. Sci; 92:2905–21.
Shibata H., Suzuki H., Yoshida H., Maki M. 2007. ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+- dependent manner. Biochem Biophys Res Commun. Feb 16;353(3):756-63. Epub 2006 Dec 22
Sierra N., Ramírez, R. Mota, D. 2000. Aislamiento del virus de PRRS en México: Estudio clínico, serológico y virológico. Archivos de medicina veterinaria; 32(1), 1-9
Vecchione A, Baldassarre G, Ishii H, Nicoloso M.S., Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM. 2007. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. Mar; 11(3):275-89.
Xie M.J., Ma Y.G., Gao F., Bai Y.G., Cheng J.H., Chang Y.M., Yu Z.B., Ma J. 2010. Activation of BKCa channel is associated with increased apoptosis of cerebrovascular smooth muscle cells in simulated microgravity rats. Am J Physiol Cell Physiol. Jun;298(6):C1489-500. doi: 10.1152/ajpcell.00474.2009.
Alonso, C., Murtaugh, M.P., Dee, S. A. & Davies, P.R. 2013. Epidemiological study of air filtration systems for preventing PRRSV infection in large sow herds. Prev. Vet. Med. 112(1–2):109–17 Balding, D.J. A.
Bergfelder-Drüing, S., Grosse-Brinkhaus, C., Lind, B., Erbe, M., Schellander, K., Simianer, H., & Tholen, E. 2015. A Genome-Wide Association Study in Large White and Landrace Pig Populations for Number Piglets Born Alive. PLoS ONE 10(3).
Boddicker, N., E.H. Waide, R.R.R. Rowland, J.K. Lunney, D.J. Garrick, J.M. Reecy, and J.C.M. Dekkers. 2012. Evidence for a major QTL associated with hot response to Porcine Reproductive and Respiratory virus syndrome challenge. J. Anim. Sci. 90:1733.
Chand R.J., Trible B.R, Rowland R.R.R. 2012. Pathogenesis of porcine reproductive and respiratory syndrome virus. Current Opinion in Virology: 2:256–263.
Charerntantanakul, W. Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects. 2012. World. J. Virol. 1(1):23–30.
Collins J.E., Mollitor T.W., Shin J.R., Pijoan C., Casamiglia M., Kapur V. 1999. Necesidad de los Médicos Veterinarios de diagnosticar enfermedades porcinas, por medio de la Reacción en Cadena de la Polimerasa (PCR). Memorias del curso “Actualidades en la Producción Porcina y en el diagnóstico de Enfermedades, México, D.F. 13-18
Flores-Mendoza, L. y Hernández, J. 2001. Vacunas contra el virus del síndrome reproductivo y respiratorio porcino (PRRSV): escribiendo una historia. Vet. México. 41:139-159.
Geldhof M.F., Breedam W.V., Jong E., Rodriguez A.L., Karniychuk U.U., Vanhee M, Doorsselaere Jv, Maes D,. Nauwynck H.J. 2013. Antibody response and maternal immunity upon boosting PRRSV-immune sows with experimental farm-specific and commercial PRRSV vaccines. Vet Microbiol;167:260–271.
Habier D., Fernando R. L., Kizilkaya K., Garrick D. J. 2011. “Extension of the Bayesian Alphabet for Genomic Selection”. BMC Bioinformatics 12:186.
Hanenberg, E. H. A. T., Knol, E. F. y Merks, J. W. M. 2001. Estimates of genetic parameters for reproduction traits at different parities in Dutch Landrace pigs. Livest. Prod. Sci. 69: 179-186.
Holtkamp D.J., Kliebenstein J.B., Neumann E.J., Zimmerman J.J., Rotto H.F., Yoder T.K., Wang C., Yeske P.E., Mowrer C.L., Haley C.A. 2013. Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. J Swine Health Prod; 21:72–84
Kikuchi M., Hatano N., Yokota S., Shimozawa N., Imanaka T., Taniguchi H. 2004. Proteomic analysis of rat liver peroxisome: Presence of peroxisome-specific isozyme of Lon protease. J Biol Chem. 2;279(1):421-8.
Kleiboeker, S. B., Schommer, S. K., Lee, S. M., Watkins, S., Chittick, W. & Polson, D. 2005. Simultaneous detection of North American and European porcine reproductive and respiratory syndrome virus using real-time quantitative reverse transcriptase–PCR. Journal Vet. Diagn. Invest. 17:165-170.
Koning D.J., Rattink B., Harlizius M.A., Groenen E.W., Brascamp 2001. Detection and characterization of Quantitative Trait Loci for growth and reproduction traits in pigs. Livestock Production Science. 72: 185-198
Lewis T. W., Wiseman J., Woolliams J.A. 2005. Genotype by mating type interaction for litter size in Landrace and Large White sows. Anim. Sci.; 81: 331-335
Lewis C.R., Ait-Ali T., Clapperton M., Archibald A.L., Bishop, S. 2007. Genetic perspectives on host responses to porcine reproductive and respiratory syndrome (PRRS). Viral Immunol ;20(3), 343-358.
Lewis C.R., Torremorell M., Galina P.L., Deeb N., Mellencamp M.A., Archibald A.L. Bishop S. A genomewide association analysis identifying SNPS for PRRS tolerance on a commercial pig farm. Proc. Assoc. Advmt. J Anim Breed Genet. 2009; (18)187–190.
Lunney J.K., Steibel J.P., Reecy J.M., Fritz E., Rothschild M.F. 2011. Probing genetic control of swine responses to PRRSV infection: current progress of the PRRS host genetics consortium. BioMed Central Ltd. pp. S30
Lunney J.K., Chen H. 2010. Genetic control of host resistance to porcine reproductive and respiratory syndrome virus (PRRSV) infection. Virus Research. 154:161–169.
Rothschild, M., Jacobson, C., Vaske, D., Tuggle, C., Wang, L., Short, T., Eckardt, G., Sasaki, S., Vincent, A., McLaren, D., Southwood, O., van der Steen, H., Mileham, A. & Plastow, G. 1996. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. . Proc Natl Acad Sci USA 93: 201–205.
Rowland R.R, 2012. Pathogenesis of porcine reproductive and respiratory syndrome virus. Current Opinion in Virology;2:256–263.
Serão, N.V.L., Matika, O., Kemp, R. A., Harding, J.C., Bishop, S. C., Plastow, G. S. & Dekkers, J.C. M. 2014. Genetic analysis of reproductive traits and antibody response in a PRRS outbreak herd. J. Anim. Sci; 92:2905–21.
Shibata H., Suzuki H., Yoshida H., Maki M. 2007. ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+- dependent manner. Biochem Biophys Res Commun. Feb 16;353(3):756-63. Epub 2006 Dec 22
Sierra N., Ramírez, R. Mota, D. 2000. Aislamiento del virus de PRRS en México: Estudio clínico, serológico y virológico. Archivos de medicina veterinaria; 32(1), 1-9
Vecchione A, Baldassarre G, Ishii H, Nicoloso M.S., Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM. 2007. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. Mar; 11(3):275-89.
Xie M.J., Ma Y.G., Gao F., Bai Y.G., Cheng J.H., Chang Y.M., Yu Z.B., Ma J. 2010. Activation of BKCa channel is associated with increased apoptosis of cerebrovascular smooth muscle cells in simulated microgravity rats. Am J Physiol Cell Physiol. Jun;298(6):C1489-500. doi: 10.1152/ajpcell.00474.2009.