Single nucleotide polymorphisms associated with services per conception in sows infected with PRRS virus
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Abstract
The porcine respiratory and reproductive syndrome (PRRS) is a disease that causes economic losses in global swine industry and is characterized by affecting the reproductive performance of sows. The objective of the present study was to identify single nucleotide polymorphisms (SNP) that are associated with the number of services per conception in the first pregnancy (NSC1) in breeding sows infected with the PRRS virus. The investigation included 53 sows Landrace/Yorkshire line previously detected as positive to PRRS virus by PCR. A blood sample from each of the sow was collected and fixed in FTA-CardsTM cards. These cards were sent to Geneseek lab for to genotype 10,000 SNP. A mixed model effects was used to identity five SNP associated to NSC1 (P<0.001), which were rs81364943, rs81382736, rs80976363, rs80890869 and rs81460050. The effect of allelic substitution was calculated using a regression model that included the term genotype as a covariate, and this model demonstrated an increasing in NCS1 of 0.41 ± 0.15, 0.11 ± 0.07, 0.23 ± 0.08, 0.15 ± 0.11 y 0.20 ± 0.09 for each SNP, respectively. These results indicate the existence of genetic basis associated with reproductive efficiency in sows infected with the PRRS virus.
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Aguilar-Trejo, C. M. (2017). Single nucleotide polymorphisms associated with services per conception in sows infected with PRRS virus. Revista Latinoamericana De Recursos Naturales, 13(2). Retrieved from https://revista.itson.edu.mx/index.php/rlrn/article/view/262
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Original Article
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
References
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Chand R.J., Trible B.R, Rowland R.R.R. 2012. Pathogenesis of porcine reproductive and respiratory syndrome virus. Current Opinion in Virology: 2:256–263.
Charerntantanakul, W. Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects. 2012. World. J. Virol. 1(1):23–30.
Collins J.E., Mollitor T.W., Shin J.R., Pijoan C., Casamiglia M., Kapur V. 1999. Necesidad de los Médicos Veterinarios de diagnosticar enfermedades porcinas, por medio de la Reacción en Cadena de la Polimerasa (PCR). Memorias del curso “Actualidades en la Producción Porcina y en el diagnóstico de Enfermedades, México, D.F. 13-18
Flores-Mendoza, L. y Hernández, J. 2001. Vacunas contra el virus del síndrome reproductivo y respiratorio porcino (PRRSV): escribiendo una historia. Vet. México. 41:139-159.
Geldhof M.F., Breedam W.V., Jong E., Rodriguez A.L., Karniychuk U.U., Vanhee M, Doorsselaere Jv, Maes D,. Nauwynck H.J. 2013. Antibody response and maternal immunity upon boosting PRRSV-immune sows with experimental farm-specific and commercial PRRSV vaccines. Vet Microbiol;167:260–271.
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Holtkamp D.J., Kliebenstein J.B., Neumann E.J., Zimmerman J.J., Rotto H.F., Yoder T.K., Wang C., Yeske P.E., Mowrer C.L., Haley C.A. 2013. Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. J Swine Health Prod; 21:72–84
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Kleiboeker, S. B., Schommer, S. K., Lee, S. M., Watkins, S., Chittick, W. & Polson, D. 2005. Simultaneous detection of North American and European porcine reproductive and respiratory syndrome virus using real-time quantitative reverse transcriptase–PCR. Journal Vet. Diagn. Invest. 17:165-170.
Koning D.J., Rattink B., Harlizius M.A., Groenen E.W., Brascamp 2001. Detection and characterization of Quantitative Trait Loci for growth and reproduction traits in pigs. Livestock Production Science. 72: 185-198
Lewis T. W., Wiseman J., Woolliams J.A. 2005. Genotype by mating type interaction for litter size in Landrace and Large White sows. Anim. Sci.; 81: 331-335
Lewis C.R., Ait-Ali T., Clapperton M., Archibald A.L., Bishop, S. 2007. Genetic perspectives on host responses to porcine reproductive and respiratory syndrome (PRRS). Viral Immunol ;20(3), 343-358.
Lewis C.R., Torremorell M., Galina P.L., Deeb N., Mellencamp M.A., Archibald A.L. Bishop S. A genomewide association analysis identifying SNPS for PRRS tolerance on a commercial pig farm. Proc. Assoc. Advmt. J Anim Breed Genet. 2009; (18)187–190.
Lunney J.K., Steibel J.P., Reecy J.M., Fritz E., Rothschild M.F. 2011. Probing genetic control of swine responses to PRRSV infection: current progress of the PRRS host genetics consortium. BioMed Central Ltd. pp. S30
Lunney J.K., Chen H. 2010. Genetic control of host resistance to porcine reproductive and respiratory syndrome virus (PRRSV) infection. Virus Research. 154:161–169.
Rothschild, M., Jacobson, C., Vaske, D., Tuggle, C., Wang, L., Short, T., Eckardt, G., Sasaki, S., Vincent, A., McLaren, D., Southwood, O., van der Steen, H., Mileham, A. & Plastow, G. 1996. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. . Proc Natl Acad Sci USA 93: 201–205.
Rowland R.R, 2012. Pathogenesis of porcine reproductive and respiratory syndrome virus. Current Opinion in Virology;2:256–263.
Serão, N.V.L., Matika, O., Kemp, R. A., Harding, J.C., Bishop, S. C., Plastow, G. S. & Dekkers, J.C. M. 2014. Genetic analysis of reproductive traits and antibody response in a PRRS outbreak herd. J. Anim. Sci; 92:2905–21.
Shibata H., Suzuki H., Yoshida H., Maki M. 2007. ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+- dependent manner. Biochem Biophys Res Commun. Feb 16;353(3):756-63. Epub 2006 Dec 22
Sierra N., Ramírez, R. Mota, D. 2000. Aislamiento del virus de PRRS en México: Estudio clínico, serológico y virológico. Archivos de medicina veterinaria; 32(1), 1-9
Vecchione A, Baldassarre G, Ishii H, Nicoloso M.S., Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM. 2007. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. Mar; 11(3):275-89.
Xie M.J., Ma Y.G., Gao F., Bai Y.G., Cheng J.H., Chang Y.M., Yu Z.B., Ma J. 2010. Activation of BKCa channel is associated with increased apoptosis of cerebrovascular smooth muscle cells in simulated microgravity rats. Am J Physiol Cell Physiol. Jun;298(6):C1489-500. doi: 10.1152/ajpcell.00474.2009.
Alonso, C., Murtaugh, M.P., Dee, S. A. & Davies, P.R. 2013. Epidemiological study of air filtration systems for preventing PRRSV infection in large sow herds. Prev. Vet. Med. 112(1–2):109–17 Balding, D.J. A.
Bergfelder-Drüing, S., Grosse-Brinkhaus, C., Lind, B., Erbe, M., Schellander, K., Simianer, H., & Tholen, E. 2015. A Genome-Wide Association Study in Large White and Landrace Pig Populations for Number Piglets Born Alive. PLoS ONE 10(3).
Boddicker, N., E.H. Waide, R.R.R. Rowland, J.K. Lunney, D.J. Garrick, J.M. Reecy, and J.C.M. Dekkers. 2012. Evidence for a major QTL associated with hot response to Porcine Reproductive and Respiratory virus syndrome challenge. J. Anim. Sci. 90:1733.
Chand R.J., Trible B.R, Rowland R.R.R. 2012. Pathogenesis of porcine reproductive and respiratory syndrome virus. Current Opinion in Virology: 2:256–263.
Charerntantanakul, W. Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects. 2012. World. J. Virol. 1(1):23–30.
Collins J.E., Mollitor T.W., Shin J.R., Pijoan C., Casamiglia M., Kapur V. 1999. Necesidad de los Médicos Veterinarios de diagnosticar enfermedades porcinas, por medio de la Reacción en Cadena de la Polimerasa (PCR). Memorias del curso “Actualidades en la Producción Porcina y en el diagnóstico de Enfermedades, México, D.F. 13-18
Flores-Mendoza, L. y Hernández, J. 2001. Vacunas contra el virus del síndrome reproductivo y respiratorio porcino (PRRSV): escribiendo una historia. Vet. México. 41:139-159.
Geldhof M.F., Breedam W.V., Jong E., Rodriguez A.L., Karniychuk U.U., Vanhee M, Doorsselaere Jv, Maes D,. Nauwynck H.J. 2013. Antibody response and maternal immunity upon boosting PRRSV-immune sows with experimental farm-specific and commercial PRRSV vaccines. Vet Microbiol;167:260–271.
Habier D., Fernando R. L., Kizilkaya K., Garrick D. J. 2011. “Extension of the Bayesian Alphabet for Genomic Selection”. BMC Bioinformatics 12:186.
Hanenberg, E. H. A. T., Knol, E. F. y Merks, J. W. M. 2001. Estimates of genetic parameters for reproduction traits at different parities in Dutch Landrace pigs. Livest. Prod. Sci. 69: 179-186.
Holtkamp D.J., Kliebenstein J.B., Neumann E.J., Zimmerman J.J., Rotto H.F., Yoder T.K., Wang C., Yeske P.E., Mowrer C.L., Haley C.A. 2013. Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. J Swine Health Prod; 21:72–84
Kikuchi M., Hatano N., Yokota S., Shimozawa N., Imanaka T., Taniguchi H. 2004. Proteomic analysis of rat liver peroxisome: Presence of peroxisome-specific isozyme of Lon protease. J Biol Chem. 2;279(1):421-8.
Kleiboeker, S. B., Schommer, S. K., Lee, S. M., Watkins, S., Chittick, W. & Polson, D. 2005. Simultaneous detection of North American and European porcine reproductive and respiratory syndrome virus using real-time quantitative reverse transcriptase–PCR. Journal Vet. Diagn. Invest. 17:165-170.
Koning D.J., Rattink B., Harlizius M.A., Groenen E.W., Brascamp 2001. Detection and characterization of Quantitative Trait Loci for growth and reproduction traits in pigs. Livestock Production Science. 72: 185-198
Lewis T. W., Wiseman J., Woolliams J.A. 2005. Genotype by mating type interaction for litter size in Landrace and Large White sows. Anim. Sci.; 81: 331-335
Lewis C.R., Ait-Ali T., Clapperton M., Archibald A.L., Bishop, S. 2007. Genetic perspectives on host responses to porcine reproductive and respiratory syndrome (PRRS). Viral Immunol ;20(3), 343-358.
Lewis C.R., Torremorell M., Galina P.L., Deeb N., Mellencamp M.A., Archibald A.L. Bishop S. A genomewide association analysis identifying SNPS for PRRS tolerance on a commercial pig farm. Proc. Assoc. Advmt. J Anim Breed Genet. 2009; (18)187–190.
Lunney J.K., Steibel J.P., Reecy J.M., Fritz E., Rothschild M.F. 2011. Probing genetic control of swine responses to PRRSV infection: current progress of the PRRS host genetics consortium. BioMed Central Ltd. pp. S30
Lunney J.K., Chen H. 2010. Genetic control of host resistance to porcine reproductive and respiratory syndrome virus (PRRSV) infection. Virus Research. 154:161–169.
Rothschild, M., Jacobson, C., Vaske, D., Tuggle, C., Wang, L., Short, T., Eckardt, G., Sasaki, S., Vincent, A., McLaren, D., Southwood, O., van der Steen, H., Mileham, A. & Plastow, G. 1996. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. . Proc Natl Acad Sci USA 93: 201–205.
Rowland R.R, 2012. Pathogenesis of porcine reproductive and respiratory syndrome virus. Current Opinion in Virology;2:256–263.
Serão, N.V.L., Matika, O., Kemp, R. A., Harding, J.C., Bishop, S. C., Plastow, G. S. & Dekkers, J.C. M. 2014. Genetic analysis of reproductive traits and antibody response in a PRRS outbreak herd. J. Anim. Sci; 92:2905–21.
Shibata H., Suzuki H., Yoshida H., Maki M. 2007. ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+- dependent manner. Biochem Biophys Res Commun. Feb 16;353(3):756-63. Epub 2006 Dec 22
Sierra N., Ramírez, R. Mota, D. 2000. Aislamiento del virus de PRRS en México: Estudio clínico, serológico y virológico. Archivos de medicina veterinaria; 32(1), 1-9
Vecchione A, Baldassarre G, Ishii H, Nicoloso M.S., Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM. 2007. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. Mar; 11(3):275-89.
Xie M.J., Ma Y.G., Gao F., Bai Y.G., Cheng J.H., Chang Y.M., Yu Z.B., Ma J. 2010. Activation of BKCa channel is associated with increased apoptosis of cerebrovascular smooth muscle cells in simulated microgravity rats. Am J Physiol Cell Physiol. Jun;298(6):C1489-500. doi: 10.1152/ajpcell.00474.2009.