Identification of Genomic Regions Associated to PRRS Vaccination Response in Replacement Gilts from South of Sonora, Mexico

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Published: Jan 1, 2017
Keywords:
replacement sows, genome, PRRS, genetic variation

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G. Luna-Nevárez
Instituto Tecnológico de Sonora

Abstract

The porcine respiratory and reproductive syndrome (PRRS) is a viral disease that seriously affects porcine production in Mexico. The most important method to prevent such disease is the vaccination of replacement sows, whose highly-variable response involves a complex genetic component. Therefore, objective of this research project is to discover genetic basis associated to a physiological-clinical indicator of vaccination response (IVR) against PRRS virus, such indicator is composed by the variables rectal temperature (TR) and daily weight gain (GPD). This study included 100 replacement sows with breed composition ¾Landrace and ¼Yorkshire, about 6-month of age, and vaccinated against PRRS using a modified live virus (day 0). Data from rectal temperature and live weight were collected the days -7, 0, 7, 14, 21, 28 and 35 after vaccination. Blood samples were obtained from each sow at day 40 after vaccination and poured on blood collection cards. The cards were processed for genomic analyses using a low density device which included 10,000 polymorphisms. A Bayesian model for genomic analysis called Bayes C was implemented in the software GenSel to study the genetic variation of the VRI explained by molecular markers previously associated to VRI. The genomic analysis detected 13 genic windows within chromosomes 3, 4, 5, 9, 12, 15, 16 and 17, which explain about 32% of the total genomic variation associated to IVR. In conclusion, there exist genetic components associated to IVRI, and this assumption is supported by the genomic analyses that suggests the IVR is gene-influenced. Therefore, this study could be proposed as an important strategy for genetic selection to identify sows with favorable response after vaccination against the PRRS virus.

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How to Cite
Luna-Nevárez, G. (2017). Identification of Genomic Regions Associated to PRRS Vaccination Response in Replacement Gilts from South of Sonora, Mexico. Revista Latinoamericana De Recursos Naturales, 13(1), 15-23. Retrieved from https://revista.itson.edu.mx/index.php/rlrn/article/view/260
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Vol 13 No 1 (2017): January-June
Section
Original Article
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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